Publication: Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20
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Issued Date
2009-01-01
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ISSN
00319422
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2-s2.0-59049083596
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.70, No.1 (2009), 121-127
Suggested Citation
Porntep Chomcheon, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20. Phytochemistry. Vol.70, No.1 (2009), 121-127. doi:10.1016/j.phytochem.2008.10.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27077
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Title
Metabolites from the endophytic mitosporic Dothideomycete sp. LRUB20
Abstract
The endophytic mitosporic Dothideomycete sp. LRUB20 was found to produce pyrone derivatives, dothideopyrones A-D (1, 3, 4, and 5), together with seven known compounds, including questin (9), asterric acid (10), methyl asterrate (11), sulochrin (12), and eugenitin (13), 6-hydroxymethyleugenitin (14), and cis, trans-muconic acid (15). Dothideopyrone D (5) and its acetate derivative 6 exhibited moderate cytotoxic activity. This is the first report on a naturally occurring muconic acid, which is commonly known as a biomarker in environments after exposure to benzene and phenol (or derivatives). Interestingly, the LRUB20 fungus could produce muconic acid in relatively high yield (47.8 mg/L). The utility of endophytic fungi in the field of white biotechnology is discussed. © 2008 Elsevier Ltd. All rights reserved.