Publication:
Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

Issued Date

2007-02-01

Resource Type

Article

ISSN

10961208
08824010

DOI

10.1016/j.micpath.2006.11.004

Other identifier(s)

2-s2.0-33847143167

Rights

Mahidol University

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SCOPUS

Bibliographic Citation

Microbial Pathogenesis. Vol.42, No.2-3 (2007), 104-110

Suggested Citation

P. Ekchariyawat, S. Pudla, K. Limposuwan, S. Arjcharoen, S. Sirisinha, P. Utaisincharoen Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization. Microbial Pathogenesis. Vol.42, No.2-3 (2007), 104-110. doi:10.1016/j.micpath.2006.11.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24582

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Title

Expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS) induced in Burkholderia pseudomallei-infected mouse macrophages requires bacterial internalization

Author(s)

P. Ekchariyawat
 S. Pudla
 K. Limposuwan
 S. Arjcharoen
 S. Sirisinha
 P. Utaisincharoen

Other Contributor(s)

Mahidol University

Abstract

We recently reported that Burkholderia pseudomallei was able to activate the expression of suppressor of cytokine signaling 3 (SOCS3) and cytokine-inducible Src homology 2-containing protein (CIS). In the present study, we presented evidence showing that the induction of these negative regulators was most probably triggered from within rather than at the cell surface of mouse macrophage cell line (RAW264.7) suggesting that macrophage activation most likely requires the interaction of bacteria with a putative host cell cytoplasmic component(s). © 2007 Elsevier Ltd. All rights reserved.

Keyword(s)

Immunology and Microbiology
 Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24582

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Scopus 2006-2010