Publication: Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers
| dc.contributor.author | C. Martin | en_US |
| dc.contributor.author | F. Gimenez | en_US |
| dc.contributor.author | K. N. Bangchang | en_US |
| dc.contributor.author | J. Karbwang | en_US |
| dc.contributor.author | R. Farinotti | en_US |
| dc.contributor.author | I. W. Wainer | en_US |
| dc.contributor.other | Hopital Pitie Salpetriere | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Universite Paris-Sud XI | en_US |
| dc.contributor.other | McGill University | en_US |
| dc.date.accessioned | 2018-02-27T04:27:46Z | |
| dc.date.available | 2018-02-27T04:27:46Z | |
| dc.date.issued | 1994-08-01 | en_US |
| dc.description.abstract | We studied the pharmacokinetics of the enantiomers of mefloquine in whole blood in healthy Thai volunteers after administration of a single oral dose of 750 mg of the racemic mixture. Mefloquine pharmacokinetics were stereoselective. The peak concentrations and areas under the curve of the (-) enantiomer were significantly higher than those of its antipode (0.79 versus 0.46 μg · ml -1 and 402 versus 94 μg · h · ml -1 ). The half-lives of (-)MQ were significantly longer than those of (+)MQ (531 versus 206 h). No stereoselectivity was observed for t max values. © 1994 Springer-Verlag. | en_US |
| dc.identifier.citation | European Journal of Clinical Pharmacology. Vol.47, No.1 (1994), 85-87 | en_US |
| dc.identifier.doi | 10.1007/BF00193485 | en_US |
| dc.identifier.issn | 14321041 | en_US |
| dc.identifier.issn | 00316970 | en_US |
| dc.identifier.other | 2-s2.0-0028026661 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/9659 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028026661&origin=inward | en_US |
| dc.subject | Medicine | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Whole blood concentrations of mefloquine enantiomers in healthy Thai volunteers | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028026661&origin=inward | en_US |