Publication: Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
Issued Date
2010-01-01
Resource Type
ISSN
14690691
Other identifier(s)
2-s2.0-85031343612
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. Vol.16, No.4 (2010), 396-399
Suggested Citation
S. Boonaiam, A. Chaiprasert, T. Prammananan, M. Leechawengwongs Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. Vol.16, No.4 (2010), 396-399. doi:10.1111/j.1469-0691.2009.02838.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29824
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Title
Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand.
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Abstract
Nucleotide sequences of genes conferring isoniazid resistance (katG, inhA, oxyR-ahpC and ndh) and ethionamide resistance (ethA) in 160 drug-resistant Mycobacterium tuberculosis clinical isolates from Thailand were analysed. Mutations in the katG gene were found in 129 isolates, predominantly at codon 315, which was mutated in 127 isolates. Twenty-two isolates had mutations in the inhA promoter and coding region. Mutations in the oxyR-ahpC intergenic region and in ndh were detected in four and one isolate(s), respectively. Of 24 ethionamide-resistant isolates, 13 had mutations in the ethA gene. However, these mutations were dispersed along the entire gene, with no codon predominating significantly.