Publication: Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
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Issued Date
2009
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Language
eng
Bibliographic Citation
Malaria Journal. Vol.8, No.1 (2009), 1-6
Suggested Citation
Izumi Naka, Nao Nishida, Jintana Patarapotikul, Pornlada Nuchnoi, Katsushi Tokunaga, Hathairad Hananantachai, Naoyuki Tsuchiya, Jun Ohashi Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria. Malaria Journal. Vol.8, No.1 (2009), 1-6. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/2112
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Title
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria
Abstract
Background: It has been previously demonstrated that a single nucleotide polymorphism (SNP)
in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to
severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster
including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects
to refine the region containing a primary variant or a haplotype susceptible to severe malaria.
Methods: A total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients
with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients).
Results: Only rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium
with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for
multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb
(from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the
promoter of IL13, but not the other genes.
Conclusion: A haplotype block in which a primary polymorphism associated with severe malaria
is likely to be encoded was identified in Thai malaria patients