Publication: Frequency of early rising parasitemia in falciparum malaria treated with artemisinin derivatives
Issued Date
2001-03-01
Resource Type
ISSN
01251562
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2-s2.0-0035288803
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 50-56
Suggested Citation
Udomsak Silachamroon, Weerapong Phumratanaprapin, Srivicha Krudsood, Sombat Treeprasertsuk, Valai Budsaratid, Karnchana Pornpininworakij, Polrat Wilairatana, Sornchai Looareesuwan Frequency of early rising parasitemia in falciparum malaria treated with artemisinin derivatives. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.32, No.1 (2001), 50-56. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26834
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Title
Frequency of early rising parasitemia in falciparum malaria treated with artemisinin derivatives
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Abstract
To define the frequency of the early rising of parasitemia in falciparum malaria patients treated with artemisinin derivatives, a retrospective chart review of 497 patients admitted to the Hospital for Tropical Diseases, Bangkok in 1996 was carried out. Early rising parasitemia, defined as an increase in the parasite count over the baseline pretreatment level during the first 24 hours of treatment, was found in 59/229 episodes (25.8%) of uncomplicated, and 111/268 episodes (41.3%) of complicated falciparum malaria. All uncomplicated cases were successfully treated without developing any complications. There were 2 deaths and 13 changes of drug regimen in the complicated group. Only one of these unfavorable responses was due to parasite response. Early rising parasitemia was very common in falciparum malaria treated with artemisinin derivatives, despite their ability to clear the parasitemia, and did not indicate failure of the drug used.