Publication: A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes
Issued Date
1996-12-01
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ISSN
0125877X
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2-s2.0-0030429672
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.14, No.2 (1996), 91-97
Suggested Citation
Napatawn Tandhanand-Banchuin, Wannapa Kespichayawatana, Sathit Vannasaeng, Suttipant Sarasombath A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes. Asian Pacific Journal of Allergy and Immunology. Vol.14, No.2 (1996), 91-97. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17609
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Title
A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes
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Abstract
In order to investigate whether there was any association between autoimmunity to pancreatic antigens with FCPD as well as IDDM, cell-mediated immune response to pancreatic antigens was studied by lymphoproliferation assay in 7 FCPD, 17 IDDM, 33 NIDDM patients and 102 normal controls. Optimal pancreatic antigen concentrations used were 100, 150 and 200 μg/ml. Positive results were considered for each concentration of antigens tested, at stimulation index (SI) > (mean ± 2 SD) SI obtained from normal age-matched controls with the use of the corresponding concentration of antigen. The one who gave positive result with any of these optimal antigen concentrations was considered to be the responder to pancreatic antigens. With this criterion, the responders were found to be 3/7 (42.9%) FCPD, 6/17 (35.3%) IDDM and 6/33 (18.2%) NIDDM patients; while there were 11 of all 102 (10.8%) normal controls.