Publication:
Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database

Issued Date

2009-04-21

Resource Type

Article

ISSN

14712334

DOI

10.1186/1471-2334-9-46

Other identifier(s)

2-s2.0-65649133108

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

BMC Infectious Diseases. Vol.9, (2009)

Suggested Citation

Jialun Zhou, Julian Elliott, Patrick C.K. Li, Poh Lian Lim, Sasisopin Kiertiburanakul, Nagalingeswaran Kumarasamy, Tuti Parwati Merati, Sanjay Pujari, Yi Ming A. Chen, Praphan Phanuphak, Saphonn Vonthanak, Thira Sirisanthana, Somnuek Sungkanuparph, Christopher K.C. Lee, Adeeba Kamarulzaman, Shinichi Oka, Fujie Zhang, Goa Tau, Rossana Ditangco Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database. BMC Infectious Diseases. Vol.9, (2009). doi:10.1186/1471-2334-9-46 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28114

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Title

Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database

Author(s)

Jialun Zhou
 Julian Elliott
 Patrick C.K. Li
 Poh Lian Lim
 Sasisopin Kiertiburanakul
 Nagalingeswaran Kumarasamy
 Tuti Parwati Merati
 Sanjay Pujari
 Yi Ming A. Chen
 Praphan Phanuphak
 Saphonn Vonthanak
 Thira Sirisanthana
 Somnuek Sungkanuparph
 Christopher K.C. Lee
 Adeeba Kamarulzaman
 Shinichi Oka
 Fujie Zhang
 Goa Tau
 Rossana Ditangco

Other Contributor(s)

Kirby Institute
 Queen Elizabeth Hospital Hong Kong
 Tan Tock Seng Hospital
 Mahidol University
 YR Gaitonde Centre for AIDS Research and Education
 Universitas Udayana
 Institute of Infectious Diseases
 National Yang-Ming University Taiwan
 The HIV Netherlands Australia Thailand Research Collaboration
 National Center for HIV/AIDS
 Research Institute for Health Sciences
 Hospital Sungai Buloh
 University of Malaya
 National Center for Global Health and Medicine
 Beijing Ditan Hospital
 Port Moresby General Hospital
 Gokila

Abstract

Background: To assess the risk and the prognostic significance of tuberculosis (TB) diagnosis in patients from The TREAT Asia HIV Observational Database, a multi-centre prospective cohort of HIV-infected patients receiving HIV care in the Asia-Pacific region. Methods: The risk of TB diagnosis after recruitment was assessed in patients with prospective follow-up. TB diagnosis was fitted as a time-dependent variable in assessing overall survival. Results: At baseline, 22% of patients were diagnosed with TB. TB incidence was 1.98 per 100 person-years during follow up, with predictors including younger age, lower recent CD4 count, duration of antiretroviral treatment, and living in high TB burden countries. Among 3279 patients during 6968 person-years, 142 died (2.04 per 100 person-years). Compared to patients with CDC category A or B illness only, mortality was marginally higher in patients with single Non-TB AIDS defining illness (ADI), or TB only (adjusted HR 1.35, p = 0.173) and highest in patients with multiple non-TB AIDS or both TB and other ADI (adjusted HR 2.21, p < 0.001). Conclusion: The risk of TB diagnosis was associated with increasing immunodeficiency and partly reduced by antiretroviral treatment. The prognosis of developing TB appeared to be similar to that following a diagnosis of other non-TB ADI. © 2009 Zhou et al; licensee BioMed Central Ltd.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/28114

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