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Interactions of Human- and Rat-Organic Anion Transporters with Pravastatin and Cimetidine

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dc.contributor.authorSuparat Khamdangen_US
dc.contributor.authorMichio Takedaen_US
dc.contributor.authorMinoru Shimodaen_US
dc.contributor.authorRie Noshiroen_US
dc.contributor.authorShinichi Narikawaen_US
dc.contributor.authorXiu Lin Huangen_US
dc.contributor.authorAtsushi Enomotoen_US
dc.contributor.authorPawinee Piyachaturawaten_US
dc.contributor.authorHitoshi Endouen_US
dc.contributor.otherKyorin University School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherTokyo University of Agriculture and Technologyen_US
dc.contributor.otherFuji Biomedix Co Ltden_US
dc.date.accessioned2018-07-24T03:57:24Z
dc.date.available2018-07-24T03:57:24Z
dc.date.issued2004-02-01en_US
dc.description.abstractWe have elucidated the interactions of human and rat organic anion transporters (hOATs and rOATs) with pravastatin and cimetidine. Pravastatin inhibited hOAT1/rOAT1, hOAT2/rOAT2, hOAT3/rOAT3, and hOAT4. The mode of inhibition was noncompetitive for hOAT1 and hOAT2, whereas it was competitive for hOAT3 and hOAT4. Cimetidine also inhibited hOAT1/rOAT1, hOAT3/rOAT3, and hOAT4. The mode of inhibition was a combination of competitive and noncompetitive manners for hOAT1, whereas it was competitive for hOAT3. The effects of OAT inhibitors on OAT1, OAT2, and OAT3 exhibited some but not so remarkable interspecies differences between humans and rats. In conclusion, we have characterized pravastatin and cimetidine as OAT inhibitors.en_US
dc.identifier.citationJournal of Pharmacological Sciences. Vol.94, No.2 (2004), 197-202en_US
dc.identifier.doi10.1254/jphs.94.197en_US
dc.identifier.issn13478613en_US
dc.identifier.other2-s2.0-1642422265en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/21807
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1642422265&origin=inwarden_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleInteractions of Human- and Rat-Organic Anion Transporters with Pravastatin and Cimetidineen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=1642422265&origin=inwarden_US

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