Publication: A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: A case report
Issued Date
2010-06-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-78649517641
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 200-205
Suggested Citation
Nongnapa Jirarattanasopa, Chutsumarn Tantikul, Pakit Vichyanond, Punchama Pacharn, Nualanong Visitsunthorn, Panthep Suttinont, Orathai Jirapongsananuruk A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: A case report. Asian Pacific Journal of Allergy and Immunology. Vol.28, No.2-3 (2010), 200-205. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29223
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A combination of intravenous immunoglobulin and pulse methylprednisolone extended survival in pulmonary alveolar proteinosis with chronic interstitial pneumonitis: A case report
Other Contributor(s)
Abstract
Pulmonary alveolar proteinosis (PAP) is characterized by intra-alveolar accumulation of lipoproteinaceous material. The severe chronic pulmonary disease and susceptibility to pulmonary infection is a prominent feature of the disease. We reported a case of postnatal-onset PAP and chronic interstitial pneumonitis in a girl with chronic respiratory distress since she was 5 months of age. A lung biopsy confirmed the diagnosis. The therapeutic bronchoalveolar lavages, a short trial of granulocyte colonystimulation factor (G-CSF) and a combination of low dose methylprednisolone and hydroxychloroquine were used at different times without noting satisfactory improvement. Intravenous immunoglobulin (IVIG) and pulse methylprednisolone were given monthly with gradual recovery. She did not require oxygen supplement after 21 months of this combination. Our report suggested that IVIG and pulse methylprednisolone might have a potential role in the treatment of PAP with chronic interstitial pneumonitis.