Publication: Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders
Issued Date
2021-08-01
Resource Type
ISSN
17448042
14622416
14622416
Other identifier(s)
2-s2.0-85114646119
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmacogenomics. Vol.22, No.12 (2021), 749-760
Suggested Citation
Aggeliki Charalampidi, Zoe Kordou, Evangelia Eirini Tsermpini, Panagiotis Bosganas, Wasun Chantratita, Koya Fukunaga, Taisei Mushiroda, George P. Patrinos, Maria Koromina Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders. Pharmacogenomics. Vol.22, No.12 (2021), 749-760. doi:10.2217/pgs-2021-0012 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76075
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Title
Pharmacogenomics variants are associated with BMI differences between individuals with bipolar and other psychiatric disorders
Abstract
Aim: Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results: Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3 and DPYD were associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion: Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.