Publication: When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia
Issued Date
2015-01-01
Resource Type
ISSN
14230410
00429007
00429007
Other identifier(s)
2-s2.0-84919674531
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vox Sanguinis. Vol.108, No.1 (2015), 1-10
Suggested Citation
A. T. Taher, A. Radwan, V. Viprakasit When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia. Vox Sanguinis. Vol.108, No.1 (2015), 1-10. doi:10.1111/vox.12201 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36790
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
When to consider transfusion therapy for patients with non-transfusion-dependent thalassaemia
Author(s)
Other Contributor(s)
Abstract
© 2014 The Authors. Non-transfusion-dependent thalassaemia (NTDT) refers to all thalassaemia disease phenotypes that do not require regular blood transfusions for survival. Thalassaemia disorders were traditionally concentrated along the tropical belt stretching from sub-Saharan Africa through the Mediterranean region and the Middle East to South and South-East Asia, but global migration has led to increased incidence in North America and Northern Europe. Transfusionists may be familiar with β-thalassaemia major because of the lifelong transfusions needed by these patients. Although patients with NTDT do not require regular transfusions for survival, they may require transfusions in some instances such as pregnancy, infection or growth failure. The complications associated with NTDT can be severe if not properly managed, and many are directly related to chronic anaemia. Awareness of NTDT is important, and this review will outline the factors that should be taken into consideration when deciding whether to initiate and properly plan for transfusion therapy in these patients in terms of transfusion interval and duration of treatment.