Publication: Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma (EPOIHCC)
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Issued Date
2013-01-01
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ISSN
14783231
14783223
14783223
Other identifier(s)
2-s2.0-84984588811
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Mahidol University
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SCOPUS
Bibliographic Citation
Liver International. Vol.33, No.3 (2013), 327-337
Suggested Citation
Joong Won Park, Deepak Amarapurkar, Yee Chao, Pei Jer Chen, Jean Francois H. Geschwind, Khean Lee Goh, Kwang Hyub Han, Masatoshi Kudo, Han Chu Lee, Rheun Chuan Lee, Laurentius A. Lesmana, Ho Yeong Lim, Seung Woon Paik, Ronnie T. Poon, Chee Kiat Tan, Tawesak Tanwandee, Gaojun Teng, Ann Lii Cheng Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma (EPOIHCC). Liver International. Vol.33, No.3 (2013), 327-337. doi:10.1111/liv.12083 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32706
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Title
Consensus recommendations and review by an International Expert Panel on Interventions in Hepatocellular Carcinoma (EPOIHCC)
Other Contributor(s)
National Cancer Center, Gyeonggi
Bombay Hospital and Medical Research Centre
Veterans General Hospital-Taipei
National Taiwan University College of Medicine
The Johns Hopkins School of Medicine
University of Malaya
Yonsei University College of Medicine
Kindai University School of Medicine
University of Ulsan, College of Medicine
Universitas Indonesia
Samsung Medical Center, Sungkyunkwan University
SungKyunKwan University, School of Medicine
The University of Hong Kong
Singapore General Hospital
Mahidol University
Southeast University
National Taiwan University Hospital
Bombay Hospital and Medical Research Centre
Veterans General Hospital-Taipei
National Taiwan University College of Medicine
The Johns Hopkins School of Medicine
University of Malaya
Yonsei University College of Medicine
Kindai University School of Medicine
University of Ulsan, College of Medicine
Universitas Indonesia
Samsung Medical Center, Sungkyunkwan University
SungKyunKwan University, School of Medicine
The University of Hong Kong
Singapore General Hospital
Mahidol University
Southeast University
National Taiwan University Hospital
Abstract
Hepatocellular carcinoma (HCC) presents with a high burden of disease in East Asian countries. Intermediate-stage HCC as defined by the Barcelona Clinic Liver Cancer (BCLC) staging system poses a clinical challenge as it includes a heterogeneous population of patients that can vary widely in terms of tumour burden, liver function and disease aetiology. Intermediate HCC patients often have unsatisfactory clinical outcomes with repeated transarterial chemoembolization (TACE, due to non-response of the target tumour or the development of further metastasis indicating progressive disease. In September 2011, an Expert Panel Opinion on Interventions in Hepatocellular Carcinoma (EPOIHCC) was convened in HK in an attempt to provide a consensus on the practice of TACE. To that end, current clinical practice throughout Asia was reviewed in detail including safety and efficacy data on TACE alone as well as in combination with targeted systemic therapies. This review summarises the evidence discussed at the meeting and provides expert recommendation regarding the available therapeutic options for unresectable intermediate stage HCC. A key consensus of the Expert Panel was that in order to improve patient outcomes and long-term survival, the possibility of using TACE in combination with targeted agents given systemically should be explored. While the currently available clinical data is promising, the expected completion of several pivotal phase II and III RCTs will provide further evidence in support of the rationale for combination therapy regimens. © 2013 John Wiley & Sons A/S.