Publication: Roles of D-amino acids on the bioactivity of host defense peptides
Issued Date
2016-04
Resource Type
Language
eng
Bibliographic Citation
International Journal of Molecular Sciences. Vol.17, 2016, 1-27
Suggested Citation
Hao Li, Nuttapat Anuwongcharoen, Aijaz Ahmad Malik, Chanin Nantasenamat Roles of D-amino acids on the bioactivity of host defense peptides. International Journal of Molecular Sciences. Vol.17, 2016, 1-27. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2133
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Roles of D-amino acids on the bioactivity of host defense peptides
Abstract
Host defense peptides (HDPs) are positively-charged and amphipathic components of the innate immune system that have demonstrated great potential to become the next generation of broad spectrum therapeutic agents effective against a vast array of pathogens and tumor. As such, many approaches have been taken to improve the therapeutic efficacy of HDPs. Amongst these methods, the incorporation of D-amino acids (D-AA) is an approach that has demonstrated consistent success in improving HDPs. Although, virtually all HDP review articles briefly mentioned about the role of D-AA, however it is rather surprising that no systematic review specifically dedicated to this topic exists, given the impact that D-AA incorporation has on HDPs. In this review, we aim to fill that void with a systematic discussion of the impact of D-AA on HDPs.