Publication: Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138
Issued Date
2015-04-24
Resource Type
ISSN
15206025
01633864
01633864
Other identifier(s)
2-s2.0-84928819084
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Natural Products. Vol.78, No.4 (2015), 615-622
Suggested Citation
Charuwan Daengrot, Vatcharin Rukachaisirikul, Chittreeya Tansakul, Tienthong Thongpanchang, Souwalak Phongpaichit, Kawitsara Bowornwiriyapan, Jariya Sakayaroj Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138. Journal of Natural Products. Vol.78, No.4 (2015), 615-622. doi:10.1021/np5005328 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35465
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Title
Eremophilane sesquiterpenes and diphenyl thioethers from the soil fungus Penicillium copticola PSU-RSPG138
Abstract
© 2015 The American Chemical Society and American Society of Pharmacognosy. Four new compounds including two eremophilane sesquiterpenes, penicilleremophilanes A (1) and B (2), as well as two sulfur-containing biphenols, penicillithiophenols A (3) and B (4), were isolated from the soil fungus Penicillium copticola PSU-RSPG138 together with 16 known compounds. Their structures were elucidated by spectroscopic methods. Known sporogen AO-1 exhibited significant antimalarial activity against Plasmodium falciparum with an IC<inf>50</inf> value of 1.53 μM and cytotoxic activity to noncancerous (Vero) cell lines with an IC<inf>50</inf> value of 4.23 μM. Although compound 1 was approximately half as active against P. falciparum with the IC<inf>50</inf> value of 3.45 μM, it showed much weaker cytotoxic activity.