Publication: The anaemia of Plasmodium vivax malaria.
Accepted Date
2012-04-17
Issued Date
2012-04-27
Copyright Date
2012
Resource Type
Language
eng
ISSN
1475-2875 (electronic)
1475-2875 (Linking)
1475-2875 (Linking)
Rights
Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Douglas NM, Anstey NM, Buffet PA, Poespoprodjo JR, Yeo TW, White NJ, et al. The anaemia of Plasmodium vivax malaria. Malar J. 2012 Apr 27;11:135.
Suggested Citation
Douglas, Nicholas M., Anstey, Nicholas M., Buffet, Pierre A., Poespoprodjo, Jeanne R., Yeo, Tsin W., White, Nicholas J., Price, Ric N. The anaemia of Plasmodium vivax malaria.. Douglas NM, Anstey NM, Buffet PA, Poespoprodjo JR, Yeo TW, White NJ, et al. The anaemia of Plasmodium vivax malaria. Malar J. 2012 Apr 27;11:135.. doi:10.1186/1475-2875-11-135. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/665
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Title
The anaemia of Plasmodium vivax malaria.
Other Contributor(s)
Abstract
Plasmodium vivax threatens nearly half the world's population and is a
significant impediment to achievement of the millennium development goals. It is
an important, but incompletely understood, cause of anaemia. This review
synthesizes current evidence on the epidemiology, pathogenesis, treatment and
consequences of vivax-associated anaemia. Young children are at high risk of
clinically significant and potentially severe vivax-associated anaemia,
particularly in countries where transmission is intense and relapses are
frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium
vivax causes similar absolute reduction in red blood cell mass because it results
in proportionately greater removal of uninfected red blood cells. Severe vivax
anaemia is associated with substantial indirect mortality and morbidity through
impaired resilience to co-morbidities, obstetric complications and requirement
for blood transfusion. Anaemia can be averted by early and effective
anti-malarial treatment.