Publication: Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales
Issued Date
2008-05-01
Resource Type
ISSN
19763786
02536269
02536269
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2-s2.0-43749109407
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Pharmacal Research. Vol.31, No.5 (2008), 611-616
Suggested Citation
Maneekarn Chinworrungsee, Suthep Wiyakrutta, Nongluksna Sriubolmas, Phitaya Chuailua, Apichart Suksamrarn Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales. Archives of Pharmacal Research. Vol.31, No.5 (2008), 611-616. doi:10.1007/s12272-001-1201-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18934
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Title
Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order hypocreales
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Abstract
Bioassay-guided fractionation of the extract of the endophytic fungus KLAR 5 belonging to order Hypocreales, which was isolated from the twig of Knema laurina (Blume) Warb., resulted in the isolation of brefeldin A (1), 8-deoxy-trichothecin (2), trichothecolone (3), 7α-hydroxytrichodermol (4), and 7α-hydroxyscirpene (5). Compound 5 was isolated from natural source for the first time. Compound 1 was very highly active against human epidermoid carcinoma of the mouth, human breast cancer (BC-1), and human small cell lung cancer (NCI-H187) cells whereas compounds 2 and 4 were selectively active against BC-1 and NCI-H187 cells. Compounds 3 and 5 were moderately active against these three cancer cell lines. © 2008 The Pharmaceutical Society of Korea.