Publication: Risk factors for gametocyte carriage in uncomplicated falciparum malaria
Issued Date
1999-01-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0032985269
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.60, No.6 (1999), 1019-1023
Suggested Citation
Ric Price, François Nosten, Julie A. Simpson, Christine Luxemburger, Lucy Phaipun, Feiko Ter Kuile, Michele Van Vugt, Tan Chongsuphajaisiddhi, Nicholas J. White Risk factors for gametocyte carriage in uncomplicated falciparum malaria. American Journal of Tropical Medicine and Hygiene. Vol.60, No.6 (1999), 1019-1023. doi:10.4269/ajtmh.1999.60.1019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25477
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Risk factors for gametocyte carriage in uncomplicated falciparum malaria
Abstract
The factors affecting the development of patent Plasmodium falciparum gametocytemia were assessed in 5,682 patients entered prospectively into a series of antimalarial drug trials conducted in an area of low and seasonal transmission on the western border of Thailand. Of the 4,565 patients with admission thick smear assessments, 110 (2.4%) had gametocytemia. During the follow-up period 170 (3%) of all patients developed patent gametocytemia, which in 89% had developed by day 14 following treatment. In a multiple logistic regression model five factors were found to be independent risk factors at presentation for the development or persistence of gametocytemia during follow up; patent gametocytemia on admission (adjusted odds ratio [AOR] = 7.8, 95% confidence interval [CI] = 3.7-16, P < 0.001), anemia (hematocrit <30%) (AOR = 3.9, 95% CI = 2.3-6.5, P < 0.001), no coincident P. vivax malaria (AOR = 3.5, 95% CI = 1.04-11.5, P < 0.04), presentation with a recrudescent infection (AOR - 2.3, 95% CI = 1.3-4.1, P < 0.004), and a history of illness longer than two days (AOR = 3.3, 95% CI = 1.7-6.6, P < 0.001). Patients whose infections responded slowly to treatment or recrudesced subsequently were also more likely to carry gametocytes than those who responded rapidly or were cured (relative risks = 1.9, 95% CI = 1.3-2.7 and 2.8, 95% CI 2.0-4.0, respectively; P < 0.001). These data provide further evidence of important epidemiologic interactions between P. falciparum and P. vivax, and drug resistance and transmission potential.