Publication: Effect of ampicillin on mefloquine pharmacokinetics in thai males
Issued Date
1991-06-01
Resource Type
ISSN
14321041
00316970
00316970
Other identifier(s)
2-s2.0-0025758449
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.40, No.6 (1991), 631-633
Suggested Citation
J. Karbwang, K. Na Bangchang, D. J. Back, D. Bunnag Effect of ampicillin on mefloquine pharmacokinetics in thai males. European Journal of Clinical Pharmacology. Vol.40, No.6 (1991), 631-633. doi:10.1007/BF00279985 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22141
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Title
Effect of ampicillin on mefloquine pharmacokinetics in thai males
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Abstract
The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml-1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg-1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 μg·ml-1 day). These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine. © 1991 Springer-verlag.
