Publication: Novel cytotoxic ring-A seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis
Issued Date
1997-01-13
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ISSN
00404020
Other identifier(s)
2-s2.0-0031013412
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tetrahedron. Vol.53, No.2 (1997), 529-538
Suggested Citation
Gloria L. Silva, Roberto R. Gil, Baoliang Cui, Heebyung Chai, Thawatchai Santisuk, Ekarath Srisook, Vichai Reutrakul, Patoomratana Tuchinda, Smaisukh Sophasan, Suparp Sujarit, Suchart Upatham, Sean M. Lynn, John E. Farthing, Shi Lin Yang, Jane A. Lewis, Melanie J. O'Neill, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn Novel cytotoxic ring-A seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis. Tetrahedron. Vol.53, No.2 (1997), 529-538. doi:10.1016/S0040-4020(96)01003-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17905
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Title
Novel cytotoxic ring-A seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis
Author(s)
Gloria L. Silva
Roberto R. Gil
Baoliang Cui
Heebyung Chai
Thawatchai Santisuk
Ekarath Srisook
Vichai Reutrakul
Patoomratana Tuchinda
Smaisukh Sophasan
Suparp Sujarit
Suchart Upatham
Sean M. Lynn
John E. Farthing
Shi Lin Yang
Jane A. Lewis
Melanie J. O'Neill
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
Roberto R. Gil
Baoliang Cui
Heebyung Chai
Thawatchai Santisuk
Ekarath Srisook
Vichai Reutrakul
Patoomratana Tuchinda
Smaisukh Sophasan
Suparp Sujarit
Suchart Upatham
Sean M. Lynn
John E. Farthing
Shi Lin Yang
Jane A. Lewis
Melanie J. O'Neill
Norman R. Farnsworth
Geoffrey A. Cordell
John M. Pezzuto
A. Douglas Kinghorn
Abstract
Coronalolide methyl ester (1), coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronaria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1-4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1. Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer cell lines.