Publication: Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum.
Accepted Date
2014-08-20
Issued Date
2014-08-29
Copyright Date
2014
Resource Type
Language
eng
ISSN
1756-3305 (electronic)
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Mahidol University
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BioMed Central
Bibliographic Citation
Yang F, Long E, Wen J, Cao L, Zhu C, Hu H. et al. Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasit Vectors. 2014 Aug 29;7:407.
Suggested Citation
Yang, Fan, Long, Erping, Wen, Juhua, Cao, Lei, Zhu, Chengcheng, Hu, Huanxin, Ruan, Ying, Kamolnetr Okanurak, กมลเนตร โอฆานุรักษ์, Hu, Huiling, Wei, Xiaoxia, Yang, Xiangyun, Wang, Chaofan, Zhang, Limei, Wang, Xiaoying, Ji, Pengyu, Zheng, Huanqin, Wu, Zhongdao, Lv, Zhiyue Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum.. Yang F, Long E, Wen J, Cao L, Zhu C, Hu H. et al. Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasit Vectors. 2014 Aug 29;7:407.. doi:10.1186/1756-3305-7-407. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/769
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Title
Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum.
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Abstract
BACKGROUND: Schistosomiasis japonicum remains a considerable economic and public
health concern in China, the Philippines and Indonesia. Currently available
measures to control the unique intermediate host Oncomelania hupensis are
frequently associated with severe side effects. Previous studies have
demonstrated that linalool-rich extracts from various plants exhibited promising
biological activities including cytotoxic, anti-microbial and anti-parasitic
properties.
METHODS: We identified the components of leaf extracts from Cinnamomum camphora
by gas chromatography coupled to mass spectrometry (GC-MS) and investigated
molluscicidal and larvicidal effects of linalool against O. hupensis and
Schistosoma japonicium. The ultrastructural alterations in gills, salivary gland,
stomach and hepatopancreas of snails were observed under the light microscope and
transmission electron microscope, and lesions to tegument of cercaria were
examined under a light microscope and fluorescence microscope. We then evaluated
the effects of linalool on skin penetration and migration of schistosomula and
adult survival by measurement of worm burden and egg counts in Balb/C mice
infected with linalool-treated cercariae.
RESULTS: In the present work, 44 components were identified from the leaf
extracts of C. camphora, of which linalool was the most abundant constituent.
Linalool exhibited the striking molluscicidal and larvicidal effects with
LC50 = 0.25 mg/L for O. hupensis and LC50 = 0.07 mg/L for cercaria of S.
japonicium. After exposure to linalool, damage to the gills and hepatopancreas of
the snails, and to the tegument and body-tail joint of cercariae was apparent. In
addition, linalool markedly reduced the recovered schistosomulum from mouse skin
after challenge infection, and therefore decreased the worm burden in infected
animals, but not fecundity of female adults of the parasite.
CONCLUSIONS: Our findings indicated that linalool might be a novel
chemotherapeutic agent against S. japonicium and the snail intermediate host.