Publication: Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)
Issued Date
2011-09-09
Resource Type
ISSN
14602180
01433334
01433334
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2-s2.0-80052409831
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Mahidol University
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SCOPUS
Bibliographic Citation
Carcinogenesis. Vol.32, No.9 (2011), 1349-1353
Suggested Citation
Joke Beuten, Jonathan A L Gelfond, Duangjai Piwkham, Brad H. Pollock, Naomi J. Winick, Anderson B. Collier, Gail E. Tomlinson Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1). Carcinogenesis. Vol.32, No.9 (2011), 1349-1353. doi:10.1093/carcin/bgr091 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/11474
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Title
Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1)
Abstract
To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 genes were significantly associated with ALL risk at the P < 0.05 level. After correction for multiple testing, rs442264 within the LIM domain only 1 (LMO1) gene at 11p15 remained significant [odds ratio (OR) = 1.90, P= 3× 10 -5 ]. In addition, a major haplotype within LMO1 comprising 14 SNPs with individual risk associations was found to significantly increase ALL risk (OR 5 1.79, P 5 0.0006). A stratified analysis on subtype indicated that risk associations of LMO1 variants are significant in children with precursor B-cell leukemia. These data show that genetic variants within LMO1 are associated with ALL and identify this gene as a strong candidate for precursor B-cell leukemogenesis. © The Author 2011. Published by Oxford University Press. All rights reserved.