Publication:
Importance of collection tube during clinical studies of oseltamivir

Issued Date

2007-05-01

Resource Type

Article

ISSN

00664804

DOI

10.1128/AAC.01534-06

Other identifier(s)

2-s2.0-34248381197

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Antimicrobial Agents and Chemotherapy. Vol.51, No.5 (2007), 1835-1836

Suggested Citation

Niklas Lindegardh, Geraint R. Davies, Tinh Hien Tran, Jeremy Farrar, Pratap Singhasivanon, Nicholas P J Day, Nicholas J. White Importance of collection tube during clinical studies of oseltamivir. Antimicrobial Agents and Chemotherapy. Vol.51, No.5 (2007), 1835-1836. doi:10.1128/AAC.01534-06 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24916

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Title

Importance of collection tube during clinical studies of oseltamivir

Author(s)

Niklas Lindegardh
 Geraint R. Davies
 Tinh Hien Tran
 Jeremy Farrar
 Pratap Singhasivanon
 Nicholas P J Day
 Nicholas J. White

Other Contributor(s)

Mahidol University
 Nuffield Department of Clinical Medicine
 University of Liverpool
 UCL

Abstract

Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60°C for 45 min. Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24916

Collections

Scopus 2006-2010