Publication: Can vaginal misoprostol effectively increase rate of a satisfactory colposcopy? A randomized double-blind placebo-controlled trial
Issued Date
2009-10-29
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ISSN
14653621
03682811
03682811
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2-s2.0-77950348737
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Mahidol University
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SCOPUS
Bibliographic Citation
Japanese Journal of Clinical Oncology. Vol.40, No.3 (2009), 203-207
Suggested Citation
Duangmani Thanapprapasr, Sarikapan Wilailak, Nathpong Israngura Na Ayudhya, Arb Aroon Lertkhachonsuk, Puchong Likittanasombut, Suwicha Chittithaworn, Chuenkamon Charakorn, Sawaek Weerakiet Can vaginal misoprostol effectively increase rate of a satisfactory colposcopy? A randomized double-blind placebo-controlled trial. Japanese Journal of Clinical Oncology. Vol.40, No.3 (2009), 203-207. doi:10.1093/jjco/hyp140 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/27130
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Title
Can vaginal misoprostol effectively increase rate of a satisfactory colposcopy? A randomized double-blind placebo-controlled trial
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Abstract
Objective: To evaluate the effectiveness of vaginal misoprostol in overcoming an unsatisfactory colposcopy in the patients who had abnormal cervical cytology and to evaluate side effects of vaginal misoprostol. Methods: Sixty patients with an unsatisfactory colposcopy during the period of September 2007-November 2008 were recruited and randomly allocated to receive either two tablets of 200 μg misoprostol (400 mg) or two tablets of similar-looking placebo vaginally. Colposcopic re-examination was performed ~6 h later. The results and side effects before and 2 weeks after the colposcopic re-examination were recorded. Results: Six out of 30 patients in the misoprostol group (20.0%) had a satisfactory colposcopic re-examination compared with 2 out of 27 patients (7.4%) in the placebo group without statistically significant difference (P = 0.172). Three patients in the placebo group dropped out due to not present at the appointment time. Six out of 30 patients (20.0%) and 1 out of 30 patients (3.3%) in the misoprostol group had side effects before and 2 weeks after the colposcopic re-examination orderly. Twenty-seven patients in the placebo group did not have any side effects before and 2 weeks after the colposcopic re-examination. All side effects occurred were minimal and well tolerated. Conclusions: Four hundred micrograms of vaginal misoprostol were not proved to be effective in converting an unsatisfactory to a satisfactory colposcopy. © The Author (2009). Published by Oxford University Press. All rights reserved.