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Polyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallocha

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dc.contributor.authorLiping Wangen_US
dc.contributor.authorXiuli Hanen_US
dc.contributor.authorGuoliang Zhuen_US
dc.contributor.authorYi Wangen_US
dc.contributor.authorArthit Chairoungduaen_US
dc.contributor.authorPawinee Piyachaturawaten_US
dc.contributor.authorWeiming Zhuen_US
dc.contributor.otherShandong University of Technologyen_US
dc.contributor.otherOcean University of Chinaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherLaboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technologyen_US
dc.contributor.otherGuizhou Medical Universityen_US
dc.date.accessioned2019-08-23T10:49:28Z
dc.date.available2019-08-23T10:49:28Z
dc.date.issued2018-08-01en_US
dc.description.abstract© 2018 Wang, Han, Zhu, Wang, Chairoungdua, Piyachaturawat and Zhu. Five new polyketides (2-6) and ten known compounds (1 and 7-15) were obtained from the fermentation products of the endophytic fungus Cladosporium sp. OUCMDZ-302 with the mangrove plant, Excoecaria agallocha (Euphorbiaceae). The new structures of 2-6 were established on the basis of ECD, specific rotation and spectroscopic data as well as the chemical calculation. Compound 7 showed cytotoxicity against H1975 cell line with an IC50 value of 10.0 μM. Compounds 4 and 8-10 showed radical scavenging activity against DPPH with the IC50 values of 2.65, 0.24, 5.66, and 6.67 μM, respectively. In addition, the absolute configuration of compound 1 was solidly determined by X-ray and sugar analysis of the acidic hydrolysates for the first time as well as those of compounds 8-10 in this paper.en_US
dc.identifier.citationFrontiers in Chemistry. Vol.6, No.AUG (2018)en_US
dc.identifier.doi10.3389/fchem.2018.00344en_US
dc.identifier.issn22962646en_US
dc.identifier.other2-s2.0-85053155671en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/45487
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053155671&origin=inwarden_US
dc.subjectChemistryen_US
dc.titlePolyketides from the endophytic fungus Cladosporium sp. isolated from the mangrove plant excoecaria agallochaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053155671&origin=inwarden_US

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