Publication: Baseline immunity to diphtheria and immunologic response after booster vaccination with reduced diphtheria and tetanus toxoid vaccine in Thai health care workers
Issued Date
2014-01-01
Resource Type
ISSN
15273296
01966553
01966553
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2-s2.0-84903313070
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Infection Control. Vol.42, No.7 (2014)
Suggested Citation
Surasak Wiboonchutikul, Weerawat Manosuthi, Chariya Sangsajja, Varaporn Thientong, Sirirat Likanonsakul, Somkid Srisopha, Patamavadee Termvises, Jitlada Rujitip, Suda Loiusirirotchanakul, Pilaipan Puthavathana Baseline immunity to diphtheria and immunologic response after booster vaccination with reduced diphtheria and tetanus toxoid vaccine in Thai health care workers. American Journal of Infection Control. Vol.42, No.7 (2014). doi:10.1016/j.ajic.2014.03.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34698
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Title
Baseline immunity to diphtheria and immunologic response after booster vaccination with reduced diphtheria and tetanus toxoid vaccine in Thai health care workers
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Abstract
A prospective study to evaluate immune status against diphtheria and immunologic response after tetanus-diphtheria (Td) booster vaccination was conducted in 250 Thai health care workers (HCWs). A protective antibody was found in 89.2% of the HCWs (95% confidence interval [CI], 83.3%-91.5%) before receipt of the Td booster vaccination, compared with 97.2% (95% CI, 95.1%-99.3%) after receipt of the first dose of booster (P <.001). The mean antibody level against diphtheria increased from 0.39 IU/mL (95% CI, 0.35-0.44 IU/mL) before the Td booster vaccination to 1.20 IU/mL (95% CI, 1.12-1.29 IU/mL) after the vaccination (P <.001). Td booster vaccination should be considered for Thai HCWs to maintain immunity against diphtheria, which still circulates in Thailand. © 2014 Published by Elsevier Inc.