Publication: Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes
Issued Date
2000-09-22
Resource Type
ISSN
00243205
Other identifier(s)
2-s2.0-0034703507
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Mahidol University
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SCOPUS
Bibliographic Citation
Life Sciences. Vol.67, No.18 (2000), 2221-2231
Suggested Citation
Sutisa Nudmamud, Pilaiwan Siripurkpong, Chittin Chindaduangratana, Ponchai Harnyuttanakorn, Pampimol Lotrakul, Wachira Laarbboonsarp, Anan Srikiatkhachorn, Naiphinich Kotchabhakdi, Stefano O. Casalotti Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes. Life Sciences. Vol.67, No.18 (2000), 2221-2231. doi:10.1016/S0024-3205(00)00806-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/25857
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Title
Stress, anxiety and peripheral benzodiazepine receptor mRNA levels in human lymphocytes
Abstract
Peripheral benzodiazepine receptor (PBR) mRNA levels were measured in lymphocytes obtained from a cohort of university students and clinically diagnosed anxious patients. The average level of PBR mRNA was decreased in anxious patients compared to a control group. This data confirms previously published results, but it also indicates that PBR mRNA levels cannot be used as a sole diagnostic measure of anxiety because the range of the individual PBR mRNA levels of the anxious group overlapped the range of the PBR mRNA levels of the control group. PBR mRNA levels in students following academic examinations were increased in some individuals and decreased in others. In the same cohort of students individual levels of cortisol and prolactin were predominantly increased and decreased respectively. There was no correlation between the individual changes in the hormone levels or PBR mRNA, which suggests that each of these parameters is affected by different environmental and physiological factors. Lymphocyte PBR mRNA measurement is a useful additional methodology for studying human stress responses however, its use in clinical studies would require the elucidation of PBR's physiological role. (C) 2000 Elsevier Science Inc.