Publication: Protective role of N-trans-feruloyltyramine against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons
Issued Date
2012-04-04
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ISSN
18727972
03043940
03043940
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2-s2.0-84858997499
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Mahidol University
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SCOPUS
Bibliographic Citation
Neuroscience Letters. Vol.513, No.2 (2012), 229-232
Suggested Citation
Wipawan Thangnipon, Nirut Suwanna, Narisorn Kitiyanant, Rungtip Soi-ampornkul, Patoomratana Tuchinda, Bamroong Munyoo, Saksit Nobsathian Protective role of N-trans-feruloyltyramine against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons. Neuroscience Letters. Vol.513, No.2 (2012), 229-232. doi:10.1016/j.neulet.2012.02.047 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15131
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Title
Protective role of N-trans-feruloyltyramine against β-amyloid peptide-induced neurotoxicity in rat cultured cortical neurons
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Abstract
Enhanced oxidative stress and inflammation play important roles in the pathogenesis of Alzheimer's disease (AD). Amyloid β-peptide (Aβ), a major component of amyloid plaques, is considered to have a causal role in the development and progress of AD by being the initiator of a pathological cascade leading to oxidative stress. The present study investigated the effect of N-trans-feruloyltyramine (NTF) purified from Polyalthia suberosa, an alkaloid shown to protect against oxidative stress and cell death. Pre-treatment of rat primary cortical cell cultures with 25-250μM NTF significantly attenuated 10μM Aβ 1-42 -induced neuronal death in a dose-dependent manner. Apoptotic cell death was demonstrated morphologically as well as by detection of the presence of activated caspase-3 and Bax, levels of which could be reduced by NTF pre-treatment. NTF also reduced production of reactive oxygen species induced by Aβ 1-42 . These findings suggest that the protective effect of NTF against Aβ 1-42 -induced neuronal death might be due to its antioxidative property. © 2012 Elsevier Ireland Ltd.