Publication: Economic evaluation and budget impact analysis of the surveillance program for hepatocellular carcinoma in thai chronic hepatitis B patients
Issued Date
2014-01-01
Resource Type
ISSN
15137368
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2-s2.0-84911010074
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.15, No.20 (2014), 8993-9004
Suggested Citation
Pannapa Sangmala, Usa Chaikledkaew, Tawesak Tanwandee, Petcharat Pongchareonsuk Economic evaluation and budget impact analysis of the surveillance program for hepatocellular carcinoma in thai chronic hepatitis B patients. Asian Pacific Journal of Cancer Prevention. Vol.15, No.20 (2014), 8993-9004. doi:10.7314/APJCP.2014.15.20.8993 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/33431
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Title
Economic evaluation and budget impact analysis of the surveillance program for hepatocellular carcinoma in thai chronic hepatitis B patients
Abstract
Background: The incidence rate and the treatment costs of hepatocellular carcinoma (HCC) are high, especially in Thailand. Previous studies indicated that early detection by a surveillance program could help by down-staging. This study aimed to compare the costs and health outcomes associated with the introduction of a HCC surveillance program with no program and to estimate the budget impact if the HCC surveillance program were implemented. Materials and Methods: A cost utility analysis using a decision tree and Markov models was used to compare costs and outcomes during the lifetime period based on a societal perspective between alternative HCC surveillance strategies with no program. Costs included direct medical, direct non-medical, and indirect costs. Health outcomes were measured as life years (LYs), and quality adjusted life years (QALYs). The results were presented in terms of the incremental cost-effectiveness ratio (ICER) in Thai THB per QALY gained. Oneway and probabilistic sensitivity analyses were applied to investigate parameter uncertainties. Budget impact analysis (BIA) was performed based on the governmental perspective. Results: Semi-annual ultrasonography (US) and semi-annual ultrasonography plus alpha-fetoprotein (US plus AFP) as the first screening for HCC surveillance would be cost-effective options at the willingness to pay (WTP) threshold of 160,000 THB per QALY gained compared with no surveillance program (ICER=118,796 and ICER=123,451THB/QALY), respectively. The semi-annual US plus AFP yielded more net monetary benefit, but caused a substantially higher budget (237 to 502 million THB) than semi-annual US (81 to 201 million THB) during the next ten fiscal years. Conclusions: Our results suggested that a semi-annual US program should be used as the first screening for HCC surveillance and included in the benefit package of Thai health insurance schemes for both chronic hepatitis B males and females aged between 40-50 years. In addition, policy makers considered the program could be feasible, but additional evidence is needed to support the whole prevention system before the implementation of a strategic plan.