Publication: Factor-associated in pattern of non-steroidal anti-inflammatory drug-induced cutaneous adverse drug reactions in the elderly
Issued Date
2018-06-01
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ISSN
01252208
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2-s2.0-85049146068
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.101, No.6 (2018), 713-719
Suggested Citation
Papapit Tuchinda, Leena Chularojanamontri, Pattriya Chanyachailert, Kanokvalai Kulthanan, Kowit Jongjarearnprasert, Panadda Uthaitas Factor-associated in pattern of non-steroidal anti-inflammatory drug-induced cutaneous adverse drug reactions in the elderly. Journal of the Medical Association of Thailand. Vol.101, No.6 (2018), 713-719. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46606
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Title
Factor-associated in pattern of non-steroidal anti-inflammatory drug-induced cutaneous adverse drug reactions in the elderly
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Abstract
© 2018, Medical Association of Thailand. All rights reserved. Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications in elderly, which can frequently cause cutaneous adverse drug reactions (ADRs). Objective: The present study aimed to investigate demographic data of elderly patients who had cutaneous reactions from NSAIDs and determine the risk factors that induce serious reactions. Materials and Methods: A retrospective analysis involving elderly patients aged 60 years or over with cutaneous ADRs suspected from NSAIDs attending the ADR Center, Siriraj Hospital, Mahidol University, Thailand, over a 4-year period. Demographic data, concurrent medications, clinical course of cutaneous ADRs and causative NSAIDs were analyzed. Results: A total of 101 patients were included. Cutaneous ADRs from NSAIDs occurred more commonly in females (65.3%). Angioedema alone was the most common cutaneous ADRs (29.7%) followed by urticaria with and without angioedema (26.7%). Forty-one patients (40.6%) were categorized as serious ADRs. Systemic reactions were significantly associated with non-selective COX inhibitors as compared to preferential and selective COX-2 inhibitors (p = 0.046). A history of severe cutaneous ADRs is significantly associated with severity of cutaneous ADRs to NSAIDs in elderly (p<0.001). Conclusion: Preferential and selective COX-2 inhibitors may be a good option for elderly due to lower risk of cutaneous ADRs. Early signs and symptoms of severe reactions should be addressed in this group of patients.