Publication: Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: A multicenter validation study
Issued Date
2021-06-01
Resource Type
ISSN
14388812
0013726X
0013726X
Other identifier(s)
2-s2.0-85092690649
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Mahidol University
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SCOPUS
Bibliographic Citation
Endoscopy. Vol.53, No.6 (2021), 595-602
Suggested Citation
Calvin Jianyi Koh, Sundeep Lakhtakia, Mitsuhiro Kida, Cosmas Rinaldi A. Lesmana, Tiing Leong Ang, Charles Kieng Fong Vu, Than Than Aye, Sun Hwa Park, Majid A. Almadi, Charing Ching Ning Chong, Raymond Shing Yan Tang, Xi Wu, Ida Hilmi, Vinay Dhir, Nonthalee Pausawasdi, Jahangeer Basha, Zhen Dong Jin, Ai Ming Yang, Anthony Yuen Bun Teoh, Dong Wan Seo, Hsiu Po Wang, Khek Yu Ho Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: A multicenter validation study. Endoscopy. Vol.53, No.6 (2021), 595-602. doi:10.1055/a-1217-3112 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/78192
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Title
Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: A multicenter validation study
Author(s)
Calvin Jianyi Koh
Sundeep Lakhtakia
Mitsuhiro Kida
Cosmas Rinaldi A. Lesmana
Tiing Leong Ang
Charles Kieng Fong Vu
Than Than Aye
Sun Hwa Park
Majid A. Almadi
Charing Ching Ning Chong
Raymond Shing Yan Tang
Xi Wu
Ida Hilmi
Vinay Dhir
Nonthalee Pausawasdi
Jahangeer Basha
Zhen Dong Jin
Ai Ming Yang
Anthony Yuen Bun Teoh
Dong Wan Seo
Hsiu Po Wang
Khek Yu Ho
Sundeep Lakhtakia
Mitsuhiro Kida
Cosmas Rinaldi A. Lesmana
Tiing Leong Ang
Charles Kieng Fong Vu
Than Than Aye
Sun Hwa Park
Majid A. Almadi
Charing Ching Ning Chong
Raymond Shing Yan Tang
Xi Wu
Ida Hilmi
Vinay Dhir
Nonthalee Pausawasdi
Jahangeer Basha
Zhen Dong Jin
Ai Ming Yang
Anthony Yuen Bun Teoh
Dong Wan Seo
Hsiu Po Wang
Khek Yu Ho
Other Contributor(s)
Siriraj Hospital
Chinese Academy of Medical Sciences & Peking Union Medical College
Chinese University of Hong Kong, Faculty of Medicine
National Taiwan University Hospital
King Khalid University Hospital
National University Hospital
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Second Military Medical University
Prince of Wales Hospital Hong Kong
Kitasato University Hospital
Asian Institute of Gastroenterology India
Changi General Hospital
University of Ulsan College of Medicine
Tan Tock Seng Hospital
Sanpya General Hospital
Global Hospitals
Medistra Hospital
Chinese Academy of Medical Sciences & Peking Union Medical College
Chinese University of Hong Kong, Faculty of Medicine
National Taiwan University Hospital
King Khalid University Hospital
National University Hospital
Universiti Malaya
NUS Yong Loo Lin School of Medicine
Second Military Medical University
Prince of Wales Hospital Hong Kong
Kitasato University Hospital
Asian Institute of Gastroenterology India
Changi General Hospital
University of Ulsan College of Medicine
Tan Tock Seng Hospital
Sanpya General Hospital
Global Hospitals
Medistra Hospital
Abstract
Background Although endoscopic ultrasound (EUS) features and criteria have been described in chronic pancreatitis, challenges remain with interoperator variability and ease of adoption. The aim of this study was to define and validate the EUS features of chronic pancreatitis in a multicenter prospective study in Asia. Method: The study was divided into two parts: the first part was conducted to derive the EUS features of chronic pancreatitis with adequate interoperator agreement; the second was to prospectively evaluate these features in a multicenter cross-sectional study and determine the optimal combination of features for the diagnosis of chronic pancreatitis. Prospectively enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination. Results: The top six EUS features that had good interobserver agreement (mean kappa 0.73, range 0.60-0.90) were selected to be further evaluated in part II of the study. These included: hyperechoic foci with shadowing, lobularity with honeycombing, cysts, dilated main pancreatic duct, dilated side branches, and calculi in the main pancreatic duct. A total of 284 subjects (132 cases, 152 controls) were enrolled from 12 centers in Asia. All six features had high accuracy ranging from 63.3% to 89.1%. Two or more of these six EUS features accurately defined chronic pancreatitis (sensitivity 94.7%, specificity 98.0%), with an area under the receiver operating curve of 0.986. Conclusion: This multicenter Asian study characterized and defined the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.