Publication: High loading fragrance encapsulation based on a polymer-blend: Preparation and release behavior
Issued Date
2010-05-01
Resource Type
ISSN
03785173
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2-s2.0-77952887487
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.391, No.1-2 (2010), 267-273
Suggested Citation
Aurapan Sansukcharearnpon, Supason Wanichwecharungruang, Natchanun Leepipatpaiboon, Teerakiat Kerdcharoen, Sunatda Arayachukeat High loading fragrance encapsulation based on a polymer-blend: Preparation and release behavior. International Journal of Pharmaceutics. Vol.391, No.1-2 (2010), 267-273. doi:10.1016/j.ijpharm.2010.02.020 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29923
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Title
High loading fragrance encapsulation based on a polymer-blend: Preparation and release behavior
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Abstract
The six fragrances, camphor, citronellal, eucalyptol, limonene, menthol and 4-tert-butylcyclohexyl acetate, which represent different chemical functionalities, were encapsulated with a polymer-blend of ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC) and poly(vinyl alcohol) (PV(OH)) using solvent displacement (ethanol displaced by water). The process gave ≥40% fragrance loading capacity with ≥80% encapsulation efficiency at the fragrance to polymer weight ratio of 1:1 and at initial polymer concentrations of 2000-16,000. ppm and the obtained fragrance-encapsulated spheres showed hydrodynamic diameters of less than 450. nm. The release profile of the encapsulated fragrances, evaluated by both thermal gravimetric and electronic nose techniques, indicated different release characteristics amongst the six encapsulated fragrances. Limonene showed the fastest release with essentially no retention by the nanoparticles, while eucalyptol and menthol showed the slowest release. © 2010 Elsevier B.V.