Publication: The analysis of preoperative wire localization in breast conserving surgery and predictors of surgical margin status
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Issued Date
2021-10-01
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01252208
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2-s2.0-85117289486
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.104, No.10 (2021), 1-9
Suggested Citation
Cholatip Wiratkapun, Pawida Wattanatada The analysis of preoperative wire localization in breast conserving surgery and predictors of surgical margin status. Journal of the Medical Association of Thailand. Vol.104, No.10 (2021), 1-9. doi:10.35755/jmedassocthai.2021.10.12771 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/77800
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Title
The analysis of preoperative wire localization in breast conserving surgery and predictors of surgical margin status
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Abstract
Background: At present, the breast conserving therapy (BCT) is considered a treatment of choice for early-stage breast cancer. BCT aims to achieve complete tumor resection with adequate margin and offers better cosmetic outcome. Objective: To describe the experience with preoperative wire localization technique for early breast cancer and analysis of factors affecting positive margin status. Materials and Methods: The authors retrospectively reviewed 190 patients with 206 malignant breast lesions treated by breast conserving surgery (BCS) after mammographic- or ultrasound- guided wire localization. Patient age, lesion type such as mass, mass with calcifications, calcifications alone, and architectural distortion, BI-RADS assessment categories, size, location, modalities of imaging guidance, number of wires used, radiological and surgical margin status, pathological diagnosis, and tumor focality were recorded. Results: A 14.56% of positive surgical margin rate was observed. Mixed-effects logistic regression analysis showed larger lesion size was a significant predictor for positive surgical margin status at larger than 1.5 cm versus 1.0 cm or smaller (p=0.033). Conclusion: The present study data suggested that larger tumor size is the only significant predictor for positive surgical margin status. To deal with non-palpable large tumor, surgeon and radiologist should pay particular attention to achieve adequate surgical margin.