Publication: Part 1: Antiplasmodial, cytotoxic, radical scavenging and antioxidant activities of thai plants in the family acanthaceae
1
Issued Date
2010-11-22
Resource Type
ISSN
14390221
00320943
00320943
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2-s2.0-78349248668
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Mahidol University
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SCOPUS
Bibliographic Citation
Planta Medica. Vol.76, No.16 (2010), 1940-1943
Suggested Citation
Panarat Charoenchai, Srunya Vajrodaya, Winai Somprasong, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Part 1: Antiplasmodial, cytotoxic, radical scavenging and antioxidant activities of thai plants in the family acanthaceae. Planta Medica. Vol.76, No.16 (2010), 1940-1943. doi:10.1055/s-0030-1250045 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28594
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Part 1: Antiplasmodial, cytotoxic, radical scavenging and antioxidant activities of thai plants in the family acanthaceae
Abstract
Crude extracts (CH2Cl2 and MeOH) of 20 plants in the family Acanthaceae were screened for their antiplasmodial, cytotoxic, antioxidant, and radical scavenging activities. These plants included Asystasia nemorum, Barleria cristata, B. strigosa, Dicliptera burmanni, Eranthemum tetragonum, Hygrophila ringens, Justicia balansae, J. procumbens, Lepidagathis incurva, Peristrophe lanceolaria, Phaulopsis dorsiflora, Ruellia kerrii, Strobilanthes auriculata, S. corrugata, S. cusia, S. dimorphotricha, S. karensium, S. maxwellii, S. pateriformis, and S. brandisii. CH 2Cl2 extracts of A. nemorum, S. corrugata, S. cusia, S. maxwellii, S. pateriformis, and S. brandisii, as well as MeOH extracts of J. balansae and J. procumbens, showed antiplasmodial activity with IC50 values of 10100μg/mL. CH2Cl2 extracts of nine plants including D. burmanni, H. ringens, J. balansae, J. procumbens, L. incurva, P. lanceolaria, P. dorsiflora, S. corrugata, and S. maxwellii showed cytotoxic activity with IC50 values of 3.546.0μg/mL. MeOH extracts (at 100μg/mL) of R. kerrii and S. auriculata could effectively scavenge DPPH free radicals (8283% inhibition) and superoxide anion radicals (79% and 88% inhibition). In the ORAC antioxidant assay, MeOH extracts of B. cristata, J. procumbens, R. kerrii, and S. auriculata exhibited activity with ORAC units of 3.13.9. © Georg Thieme Verlag KG Stuttgart · New York.