Publication: Synergism of antimalarial antibiotics with hydrogen peroxide in inhibiting plasmodium falciparum growth in culture
Issued Date
2014-01-01
Resource Type
ISSN
01251562
Other identifier(s)
2-s2.0-84899550131
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.45, No.1 (2014), 1-5
Suggested Citation
Sugunya Utaida, Saranya Auparakkitanon, Prapon Wilairat Synergism of antimalarial antibiotics with hydrogen peroxide in inhibiting plasmodium falciparum growth in culture. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.45, No.1 (2014), 1-5. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34555
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Synergism of antimalarial antibiotics with hydrogen peroxide in inhibiting plasmodium falciparum growth in culture
Other Contributor(s)
Abstract
Although morbidity and mortality from malaria have steadily decreased worldwide, the ever present menace of the appearance of Plasmodium falciparum resistant to all antimalarials in current use, including most recently to artemisinin and its analogs, is of utmost concern, especially when development of new and affordable antimalarials has not kept abreast of this phenomenon. An alternative approach is to identify synergistic drug combinations, which would allow employment of otherwise non-efficacious antimalarial drugs. This study demonstrates that combinations of the chemical oxidant hydrogen hydroxide with antimalarial antibiotics targeting parasite mitochondrial and apicoplast ribosomes, which normally produce 'delayed-death' of parasites, act synergistically to inhibit P. falciparum growth in culture.