Publication: Short report: Evaluation of loop-mediated isothermal amplification (LAMP) for malaria diagnosis in a field setting
Issued Date
2011-10-01
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ISSN
00029637
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2-s2.0-80053913069
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.85, No.4 (2011), 594-596
Suggested Citation
Jeeraphat Sirichaisinthop, Sureemas Buates, Risa Watanabe, Eun Taek Han, Wachira Suktawonjaroenpon, Somporn Krasaesub, Satoru Takeo, Takafumi Tsuboi, Jetsumon Sattabongkot Short report: Evaluation of loop-mediated isothermal amplification (LAMP) for malaria diagnosis in a field setting. American Journal of Tropical Medicine and Hygiene. Vol.85, No.4 (2011), 594-596. doi:10.4269/ajtmh.2011.10-0676 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11987
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Title
Short report: Evaluation of loop-mediated isothermal amplification (LAMP) for malaria diagnosis in a field setting
Abstract
We used the loop-mediated isothermal amplification (LAMP) method developed by our group for malaria diagnosis with genus-specific and species-specific primers for the four human malaria parasites at a field clinic in comparison with standard microscopy. Among 110 blood samples collected from the malaria clinic in Thailand, LAMP detected 59 of 60 samples positive by microscopy (sensitivity = 98.3%) and none of the 50 microscopy-negative samples (specificity = 100%). Negative predictive value (NPV) and positive predictive value (PPV) of LAMP were 98% and 100%, respectively. These results indicate that LAMP is an effective tool for malaria diagnosis at a field clinic in a field setting. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.