Publication: Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand
Issued Date
2014-01-01
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ISSN
14735571
02699370
02699370
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2-s2.0-84906724853
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Mahidol University
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SCOPUS
Bibliographic Citation
AIDS. Vol.28, No.14 (2014), 2071-2079
Suggested Citation
Prakul Chanthong, Keswadee Lapphra, Supawan Saihongthong, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Wanatpreeya Phongsamart, Supattra Rungmaitree, Nantaka Kongstan, Kulkanya Chokephaibulkit Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand. AIDS. Vol.28, No.14 (2014), 2071-2079. doi:10.1097/QAD.0000000000000376 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34035
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Title
Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand
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Abstract
Objectives: To evaluate the carotid intima-media thickness (cIMT) in perinatally HIVinfected adolescents and factors associated with cardiovascular abnormalities. Designs: A cross-sectional study was conducted in perinatally HIV-infected adolescents who had no known cardiovascular condition and healthy controls. Methods: Transthoracic echocardiogram and cIMT measurements were taken by pediatric cardiologists. Serum lipid profiles, high-sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide were measured. Results: Hundred HIV-infected and 50 healthy adolescents were enrolled. Echocardiograms revealed overall normal systolic function (median left-ventricular ejection fraction 66 vs. 66%; P=0.825). The mean overall cIMTs of common carotid arteries and internal carotid arteries were not different between the groups (0.373 vs. 0.371; P=0.744). Among the HIV-infected adolescents, those who had been receiving protease inhibitor-containing regimens had an increased cIMT (0.364 vs. 0.381mm; P=0.009). Hypertriglyceridemia was found in 52% of those who had received protease inhibitors for more than 6 months, but only in 21% of those who had never received protease inhibitors (odds ratio 4.0, 95% confidence interval 1.6-9.7, P=0.002). Current HIV-RNA, CD4+, BMI, sex, cholesterol and low-density lipoprotein-cholesterol were not associated with increased cIMT. Serum high-sensitivity C-reactive protein and N-terminal pro-brain natriuretic peptide were not different between the groups and not associated with cardiac abnormalities. Conclusions: Perinatally HIV-infected adolescents had comparable myocardial function and similar cIMT measurements to healthy adolescents. However, hypertriglyceridemia and increased cIMT were found in HIV-infected adolescents receiving protease inhibitor-based regimens. Longer-term follow-up is needed to evaluate HIV-associated cardiovascular disease risk in this population. © 2014 Wolters Kluwer Health.