Publication: Association of CETP gene variants with atherogenic dyslipidemia among thai patients treated with statin
Issued Date
2021-01-01
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ISSN
11787066
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2-s2.0-85099663996
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmacogenomics and Personalized Medicine. Vol.14, (2021), 1-13
Suggested Citation
Pornpen Srisawasdi, Punyanuch Rodcharoen, Somlak Vanavanan, Anchalee Chittamma, Chonlaphat Sukasem, Chalitpon Na Nakorn, Charungthai Dejthevaporn, Martin H. Kroll Association of CETP gene variants with atherogenic dyslipidemia among thai patients treated with statin. Pharmacogenomics and Personalized Medicine. Vol.14, (2021), 1-13. doi:10.2147/PGPM.S278671 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/76414
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Title
Association of CETP gene variants with atherogenic dyslipidemia among thai patients treated with statin
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Abstract
Objective: Patients treated with statins for dyslipidemia may still have a residual risk of atherosclerotic cardiovascular disease (ASCVD). To determine whether genetic variants in the cholesteryl ester transport protein (CETP), rs3764261 (C>A), rs708272 (G>A), and rs12149545 (G>A) affect ASCVD risk, we studied the association of these variants with dyslipidemia in statin-treated patients. Patients and Methods: We included 299 adult Thai patients treated with a statin (95 men and 204 women). Genotyping was performed by conducting a TaqMan real-time polymerase chain reaction-based analysis. We used logistic regression models adjusted for potential confounders of age, body mass index, blood pressure, insulin resistance, and statin dosage to analyze the association between CETP variants and atherogenic lipoprotein patterns. Results: CETP polymorphisms of rs3764261 and rs708272, but not rs12149545, were significantly associated with high-density lipoprotein cholesterol (HDL-C), apoA-I, triglycerides, very low-density lipoprotein (VLDL)-C, and large LDL (LDL1-C) levels as well as mean LDL particle size (all p < 0.020). However, no significant difference was observed in total cholesterol, LDL-C, or apoB levels by CETP variants. Regardless of sex, the combination of rs3764261 (CC genotype) and rs708272 (GG or GA genotypes) showed a stronger association with atherogenic dyslipidemia, including features of decreased HDL-C, elevated triglycerides, and LDL subclass pattern B (odds ratio [OR] = 2.99, 95% confidence interval [CI]: 1.78–5.02) compared with the single variant rs3764261 (OR = 2.11, 95% CI: 1.27–3.50) or rs708272 (OR = 2.12, 95% CI: 1.29–3.49). Conclusion: The polymorphisms of CETP rs3764261 (CC genotype) and rs708272 (GG and GA genotypes) may have a higher susceptibility to atherogenic dyslipidemia. Testing for CETP rs3764261 and rs708272 may serve as a surrogate marker for lipid management in statin-treated patients, which may help individualize treatment for reducing the residual risk of ASCVD.