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Three novel single nucleotide polymorphisms of UGT1A9 in a Thai population

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dc.contributor.authorPorntipa Korprasertthawornen_US
dc.contributor.authorWandee Udomuksornen_US
dc.contributor.authorKrongtong Yoovathawornen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPrince of Songkla Universityen_US
dc.date.accessioned2018-09-13T07:07:50Z
dc.date.available2018-09-13T07:07:50Z
dc.date.issued2009-01-01en_US
dc.description.abstractThe human UDP-glucuronosyltransferase, UGT1A9, catalyzes glucuronidation of various endobiotics and xenobiotics. In this study, we sequenced the promoter and exon 1 regions of the UGT1A9 gene in 93 Thai individuals and identified 7 genetic polymorphisms. The allele frequencies of all 3 novel single nucleotide polymorphisms (SNPs): 454A>G and 455A>C (N152A) and 760C>T (R254X) were 0.005. The other 4 known polymorphisms, -688A>C, 440T>C, 331C>T -118A(T)10AT (UGT1A9*1b), were identified and found to have frequencies of 0.124, 0.978, 0.968 and 0.532, respectively.en_US
dc.identifier.citationDrug Metabolism and Pharmacokinetics. Vol.24, No.5 (2009), 482-485en_US
dc.identifier.doi10.2133/dmpk.24.482en_US
dc.identifier.issn18800920en_US
dc.identifier.issn13474367en_US
dc.identifier.other2-s2.0-71449126247en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/28259
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=71449126247&origin=inwarden_US
dc.subjectMedicineen_US
dc.subjectPharmacology, Toxicology and Pharmaceuticsen_US
dc.titleThree novel single nucleotide polymorphisms of UGT1A9 in a Thai populationen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=71449126247&origin=inwarden_US

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