White, Nicholas J, Guo Qiao, Li, Qi, Gao, Luzzatto, Lucio Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malaria Journal. Vol.11, (2012), 418. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/2803
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Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common
In areas of low malaria transmission, it is currently recommended that a single dose of primaquine (0.75 mg base/kg;
45 mg adult dose) be added to artemisinin combination treatment (ACT) in acute falciparum malaria to block malaria
transmission. Review of studies of transmission-blocking activity based on the infectivity of patients or volunteers to
anopheline mosquitoes, and of haemolytic toxicity in glucose 6-dehydrogenase (G6PD) deficient subjects, suggests that
a lower primaquine dose (0.25 mg base/kg) would be safer and equally effective. This lower dose could be deployed
together with ACTs without G6PD testing wherever use of a specific gametocytocide is indicated.
