Publication: Pharmacokinetics and bioavailability of oral and intramuscular artemether
Issued Date
1997-07-18
Resource Type
ISSN
00316970
Other identifier(s)
2-s2.0-0030786432
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Clinical Pharmacology. Vol.52, No.4 (1997), 307-310
Suggested Citation
J. Karbwang, K. Na-Bangchang, K. Congpuong, P. Molunto, A. Thanavibul Pharmacokinetics and bioavailability of oral and intramuscular artemether. European Journal of Clinical Pharmacology. Vol.52, No.4 (1997), 307-310. doi:10.1007/s002280050295 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18110
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Pharmacokinetics and bioavailability of oral and intramuscular artemether
Other Contributor(s)
Abstract
Objective: The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study. Results: Both oral and intramuscular artemether were well-tolerated. In most cases, artemether and dihydroartemisinin were detected in plasma after 30 min and declined to levels below the limit of detection within 18-24 h. Compared with intramuscular administration, oral administration of artemether resulted in a relatively rapid but incomplete absorption [C(max): 474 vs 540 ng·ml-1; t(max): 2.0 vs 3.9 h; AUC: 2.17 vs 5.20 μg·h·ml-1]. Geographic means of lag-time and absorption half-life (t( 1/4 a)) of oral vs intramuscular artemether were 0.28 and 1.1 h vs 0.30 and 2 h, respectively. t(t 1/4 z) was significantly shortened after the oral dose [2.8 vs 6.9 h]. Mean oral bioavailability relative to intramuscular administration was 43.2%. The ratio of the AUCs of artemether to dihydroartemisinin was significantly lower after the oral than after the intramuscular dose (geometric mean: 0.29 vs 0.60).