Publication: Breast cancer upregulating genes in stromal cells by LINE-1 hypermethylation and micrometastatic detection
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Issued Date
2016-04-01
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ISSN
1750192X
17501911
17501911
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2-s2.0-84964923704
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Mahidol University
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SCOPUS
Bibliographic Citation
Epigenomics. Vol.8, No.4 (2016), 475-486
Suggested Citation
Charoenchai Puttipanyalears, Nakarin Kitkumthorn, Supranee Buranapraditkun, Somboon Keelawat, Apiwat Mutirangura Breast cancer upregulating genes in stromal cells by LINE-1 hypermethylation and micrometastatic detection. Epigenomics. Vol.8, No.4 (2016), 475-486. doi:10.2217/epi-2015-0007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43062
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Title
Breast cancer upregulating genes in stromal cells by LINE-1 hypermethylation and micrometastatic detection
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Abstract
© 2016 Future Medicine Ltd. Changes in the methylation level of genes containing LINE-1 alter host gene regulation. Aim: This study demonstrates that paracrine signaling of breast cancer influences the epigenetic regulation of stromal cells. Methods: We proved in vitro and in vivo breast cancer promoted LINE-1 methylation exists exclusively in female stromal cells. Results: Genes containing LINE-1 of breast cancer stromal cells were upregulated. Furthermore, one of the genes, MUC-1, was demonstrated to have expression in plasma cells from the lymph nodes of patients with lymph node metastasis or micrometastasis. Conclusion: Breast cancer sends a paracrine signal to stroma cells causing LINE-1 epigenetic regulation. Moreover, the regulated genes in stroma cells are potential biomarkers for detecting breast cancer micrometastasis.