Asian Pacific Journal of Allergy and Immunology. Vol.19, No.1 (2001), 17-22
Suggested Citation
W. Kantakamalakul, J. Cox, U. Kositanont, S. Siritantikorn, K. Limbach, D. Birx, P. Thongcharoen, P. Puthavathana Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais. Asian Pacific Journal of Allergy and Immunology. Vol.19, No.1 (2001), 17-22. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26559
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Cytotoxic T lymphocyte responses to vaccinia virus antigens but not HIV-1 subtype E envelope protein seen in HIV-1 seronegative Thais
The HIV-1 prime boost phase I/II vaccine trial using a recombinant canarypox vector, vCP1521, containing subtype E env (gp120), and subtype B env (gp41), gag and protease has started in Thailand. We have demonstrated that although 4 from 15 human immunodeficiency virus type 1 (HIV-1) seronegative individuals showed cytotoxic T lymphocyte (CTL) responses to vaccinia virus antigens, none of them showed specific CTL responses to subtype E Env after in vitro stimulation. This preliminary study suggests that specific CTL responses to subtype E envelope detected in HIV-1 seronegative individuals after vaccination should be considered as specific responses to the immunization.
