Publication: Host-parasite network structure is associated with community-level immunogenetic diversity
Issued Date
2014-10-14
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ISSN
20411723
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2-s2.0-84924170158
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Communications. Vol.5, (2014)
Suggested Citation
Shai Pilosof, Miguel A. Fortuna, Jean François Cosson, Maxime Galan, Chaisiri Kittipong, Alexis Ribas, Eran Segal, Boris R. Krasnov, Serge Morand, Jordi Bascompte Host-parasite network structure is associated with community-level immunogenetic diversity. Nature Communications. Vol.5, (2014). doi:10.1038/ncomms6172 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33218
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Title
Host-parasite network structure is associated with community-level immunogenetic diversity
Other Contributor(s)
Ben-Gurion University of the Negev
CSIC- Estación Biológica de Doñana EBD
Montpellier SupAgro
Mahidol University
Rajabhat University
Weizmann Institute of Science Israel
CNRS Centre National de la Recherche Scientifique
CIRAD Centre de Recherche de Montpellier
Centre d'Infectiologie Christophe Mérieux du Laos
CSIC- Estación Biológica de Doñana EBD
Montpellier SupAgro
Mahidol University
Rajabhat University
Weizmann Institute of Science Israel
CNRS Centre National de la Recherche Scientifique
CIRAD Centre de Recherche de Montpellier
Centre d'Infectiologie Christophe Mérieux du Laos
Abstract
© 2014 Macmillan Publishers Limited. All rights reserved. Genes of the major histocompatibility complex (MHC) encode proteins that recognize foreign antigens and are thus crucial for immune response. In a population of a single host species, parasite-mediated selection drives MHC allelic diversity. However, in a community-wide context, species interactions may modulate selection regimes because the prevalence of a given parasite in a given host may depend on its prevalence in other hosts. By combining network analysis with immunogenetics, we show that host species infected by similar parasites harbour similar alleles with similar frequencies. We further show, using a Bayesian approach, that the probability of mutual occurrence of a functional allele and a parasite in a given host individual is nonrandom and depends on other host-parasite interactions, driving co-evolution within subgroups of parasite species and functional alleles. Therefore, indirect effects among hosts and parasites can shape host MHC diversity, scaling it from the population to the community level.