Publication: Reduction of LDL-cholesterol in mildly hypercholesterolemic thais with plant stanol ester fortified soy milk
Issued Date
2011-11-01
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ISSN
01252208
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2-s2.0-84856980974
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.94, No.11 (2011), 1327-1336
Suggested Citation
Wantanee Kriengsinyos, Kanitsorn Sumriddetchkajorn, Uruwan Yamborisut Reduction of LDL-cholesterol in mildly hypercholesterolemic thais with plant stanol ester fortified soy milk. Journal of the Medical Association of Thailand. Vol.94, No.11 (2011), 1327-1336. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/12230
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Title
Reduction of LDL-cholesterol in mildly hypercholesterolemic thais with plant stanol ester fortified soy milk
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Abstract
Objective: To investigate the effects of soymilk fortified with plant stanol ester on changes in LDL-cholesterol, fat-soluble vitamins and sex hormones in Thai volunteers. Material and Method: In a double-blind, placebo-controlled study, 120 mildly hypercholesterolemic Thais were randomly assigned to stanol and control groups that were comparable in lipid profile and body mass index. Subjects consumed regular or 2g stanol-containing soymilk once a day and postprandially for six weeks. The serum lipid profile was measured at weeks 0, 2 and 6; serum fat-soluble vitamins and sex hormones were measured at weeks 0 and 6. Results: The mean reduction in total cholesterol was 8.2 % in the stanol group (p < 0.0001) and 0.6% in the control group. LDL-cholesterol declined in both groups at week two, but the reduction was maintained to week six only in the stanol group. The mean reduction in LDL-cholesterol was 13.5% in the stanol group (p < 0.0001) at week 6, compared to a 4.6% decrease in the control group. Adjusted serum β-cryptoxantene and β-carotene levels decreased at week six for the stanol group. Serum sex hormone levels in both groups remained unchanged. Conclusion: Consumption of stanol-ester-containing soymilk for six weeks significantly reduced LDL-cholesterol in mildly hypercholesterolemic Thais. No adverse effect on sex hormones was observed. However, stanol-ester consumers are at risk of fat-soluble-vitamin deficiencies if the vitamin intake from foods is inadequate.