Publication:
A SYNDROME OF HYPERTENSION, CONVULSION, AND CEREBRAL HÆMORRHAGE IN THALASSÆMIC PATIENTS AFTER MULTIPLE BLOOD-TRANSFUSIONS

Issued Date

1978-09-16

Resource Type

Article

ISSN

01406736

DOI

10.1016/S0140-6736(78)92824-6

Other identifier(s)

2-s2.0-0018178479

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

The Lancet. Vol.312, No.8090 (1978), 602-604

Suggested Citation

P. Wasi, P. Pootrakul, A. Piankijagum, S. Na-Nakorn, D. Sonakul, P. Pacharee A SYNDROME OF HYPERTENSION, CONVULSION, AND CEREBRAL HÆMORRHAGE IN THALASSÆMIC PATIENTS AFTER MULTIPLE BLOOD-TRANSFUSIONS. The Lancet. Vol.312, No.8090 (1978), 602-604. doi:10.1016/S0140-6736(78)92824-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13102

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Title

A SYNDROME OF HYPERTENSION, CONVULSION, AND CEREBRAL HÆMORRHAGE IN THALASSÆMIC PATIENTS AFTER MULTIPLE BLOOD-TRANSFUSIONS

Author(s)

P. Wasi
 P. Pootrakul
 A. Piankijagum
 S. Na-Nakorn
 D. Sonakul
 P. Pacharee

Other Contributor(s)

Mahidol University

Abstract

Various combinations of hypertension, convulsion, severe headache, and cerebral hæmorrhage appeared in eight thalassæmic patients after they had received 3-7 units of blood in preparation for splenectomy. Intracranial hæmorrhage definitely developed in four patients, three of whom died. At necropsy the brains showed changes similar to those of hypertensive cerebral hæmorrhage and hypertensive encephalopathy. It is believed that hypertension initiates this syndrome. Since the episodes often occurred days, as long as 15 days, after the last unit of blood was transfused, hypertension did not seem to result from volume overload, but probably from vasopressive substances provided by or occurring in association with multiple blood-transfusions. Host factors may also contribute. © 1978.

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/13102

Collections

Scopus 1969-1990