Relationship between serum antioxidant vitamins A, E, and C and lipid profiles in priest subjects at the Priest Hospital.

Abstract

The serum vitamins A, E, and C (antioxidant vitamins) of 112 priest subjects, compared with 90 males and 119 females in a control group, were investigated. Subjects for the study were Thai volunteers who attended the Outpatient Department, Priest Hospital, Bangkok, for a physical check-up from July to September 2003. There was no age difference between the priest group and the controls. All serum vitamins, A, E, and C, of the priest group were significantly lower than the control group. Statistically significantly higher levels of total cholesterol, LDL-C, and LDL-C/HDL-C ratio were found in the priest subjects compared with the controls. The median serum retinol concentration in the priest subjects was 3.02 micromol/l (range 1.47-4.01 micromol/l) compared with 3.23 micromol/l (range 1.74-4.57 micromol/l) in the controls (p<0.01). The median serum a-tocopherol concentration in the priest subjects was 18.1 mmol/l (range 5.8-27.3 micromol/l) compared with 19.6 mmol/l (range 7.3-37.7 micromol/l) in the controls (p<0.01). The median serum ascorbic acid concentration in the priest subjects was 3.74 mg/l (range 0.0-17.0 mg/l) compared with 6.37 mg/l (range 0.0-18.0 mg/l) in the controls. The median values for retinol, alpha-tocopherol, and ascorbic acid serum concentrations in the male priests were lower than the control males. A total of 28% and 65% of the priest subjects had decreased alpha-tocopherol and ascorbic acid levels, while the controls had decreased alpha-tocopherol and ascorbic acid levels of 20% and 31.5%, respectively. A total of 67.8% and 54.4% of priest and control subjects, respectively, had cholesterol concentrations of > or = 5.18 mmol/l. However, a prevalence of low HDL-C (HDL-C < or = 0.91 micromol/l) was found in 1.8% of priest subjects and 1.4% of controls. Statistically significant associations were found between alpha-tocopherol, cholesterol, LDL-C, triglyceride, and serum retinol. A positive correlation was found between age, retinol, and serum alpha-tocopherol. A negative correlation was found between cholesterol, HDL-C, LDL-C, and the serum alpha-tocopherol/cholesterol ratio. In addition, negative correlations were found between weight, cholesterol, LDL-C, triglyceride, and the serum alpha-tocopherol/(cholesterol + triglyceride) ratio in priest and control subjects. The results suggest more research should be conducted into the health and nutritional problems of both healthy and diseased priest subjects concerning vitamins and oxidative stress.