Publication:
Prognostic significance of the interval between the initiation of antiretroviral therapy and the initiation of anti-tuberculosis treatment in HIV/tuberculosis-coinfected patients: Results from the TREAT Asia HIV Observational Database

Issued Date

2014-02-01

Resource Type

Article

ISSN

14681293
14642662

DOI

10.1111/hiv.12073

Other identifier(s)

2-s2.0-84891828094

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

HIV Medicine. Vol.15, No.2 (2014), 77-85

Suggested Citation

S. H. Han, J. Zhou, M. P. Lee, H. Zhao, Y. M.A. Chen, N. Kumarasamy, S. Pujari, C. Lee, S. F.S. Omar, R. Ditangco, N. Phanuphak, S. Kiertiburanakul, R. Chaiwarith, T. P. Merati, E. Yunihastuti, J. Tanuma, V. Saphonn, A. H. Sohn, J. Y. Choi, C. V. Mean, V. Saphonn, K. Vohith, F. J. Zhang, H. X. Zhao, N. Han, P. C.K. Li, M. P. Lee, N. Kumarasamy, S. Saghayam, C. Ezhilarasi, S. Pujari, K. Joshi, A. Makane, D. N. Wirawan, F. Yuliana, E. Yunihastuti, D. Imran, A. Widhani, S. Oka, J. Tanuma, T. Nishijima, J. Y. Choi, S. H. Han, J. M. Kim, C. K.C. Lee, B. L.H. Sim, R. David, A. Kamarulzaman, A. Kajindran, R. Ditangco, E. Uy, R. Bantique, Y. M.A. Chen, W. W. Wong, L. H. Kuo, O. T. Ng, A. Chua, L. S. Lee, A. Loh, P. Phanuphak, K. Ruxrungtham, M. Khongphattanayothin, S. Sungkanuparph, N. Sanmeema, T. Sirisanthana, R. Chaiwarith, W. Kotarathititum, V. K. Nguyen, V. H. Bui, T. T. Cao, T. T. Pham, D. D. Cuong, H. L. Ha, A. H. Sohn, N. Durier, D. A. Cooper, B. Petersen, J. Zhou, A. Jiamsakul Prognostic significance of the interval between the initiation of antiretroviral therapy and the initiation of anti-tuberculosis treatment in HIV/tuberculosis-coinfected patients: Results from the TREAT Asia HIV Observational Database. HIV Medicine. Vol.15, No.2 (2014), 77-85. doi:10.1111/hiv.12073 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34311

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Prognostic significance of the interval between the initiation of antiretroviral therapy and the initiation of anti-tuberculosis treatment in HIV/tuberculosis-coinfected patients: Results from the TREAT Asia HIV Observational Database

Author(s)

S. H. Han
 J. Zhou
 M. P. Lee
 H. Zhao
 Y. M.A. Chen
 N. Kumarasamy
 S. Pujari
 C. Lee
 S. F.S. Omar
 R. Ditangco
 N. Phanuphak
 S. Kiertiburanakul
 R. Chaiwarith
 T. P. Merati
 E. Yunihastuti
 J. Tanuma
 V. Saphonn
 A. H. Sohn
 J. Y. Choi
 C. V. Mean
 V. Saphonn
 K. Vohith
 F. J. Zhang
 H. X. Zhao
 N. Han
 P. C.K. Li
 M. P. Lee
 N. Kumarasamy
 S. Saghayam
 C. Ezhilarasi
 S. Pujari
 K. Joshi
 A. Makane
 D. N. Wirawan
 F. Yuliana
 E. Yunihastuti
 D. Imran
 A. Widhani
 S. Oka
 J. Tanuma
 T. Nishijima
 J. Y. Choi
 S. H. Han
 J. M. Kim
 C. K.C. Lee
 B. L.H. Sim
 R. David
 A. Kamarulzaman
 A. Kajindran
 R. Ditangco
 E. Uy
 R. Bantique
 Y. M.A. Chen
 W. W. Wong
 L. H. Kuo
 O. T. Ng
 A. Chua
 L. S. Lee
 A. Loh
 P. Phanuphak
 K. Ruxrungtham
 M. Khongphattanayothin
 S. Sungkanuparph
 N. Sanmeema
 T. Sirisanthana
 R. Chaiwarith
 W. Kotarathititum
 V. K. Nguyen
 V. H. Bui
 T. T. Cao
 T. T. Pham
 D. D. Cuong
 H. L. Ha
 A. H. Sohn
 N. Durier
 D. A. Cooper
 B. Petersen
 J. Zhou
 A. Jiamsakul

Other Contributor(s)

Yonsei University College of Medicine
 University of New South Wales (UNSW) Australia
 Queen Elizabeth Hospital Hong Kong
 Beijing Ditan Hospital
 National Yang-Ming University Taiwan
 YR Gaitonde Centre for AIDS Research and Education
 Institute of Infectious Diseases
 Hospital Sungai Buloh
 University of Malaya Medical Centre
 Gokila
 The HIV Netherlands Australia Thailand Research Collaboration
 Mahidol University
 Research Institute for Health Sciences
 Universitas Udayana
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 National Center for Global Health and Medicine
 National Center for HIV/AIDS
 Foundation for AIDS Research
 Tan Tock Seng Hospital
 National Hospital for Tropical Diseases
 Bach Mai Hospital
 amfAR - The Foundation for AIDS Research

Abstract

Objectives: We evaluated the effect of the time interval between the initiation of antiretroviral therapy (ART) and the initiation of tuberculosis (TB) treatment on clinical outcomes in HIV/TB-coinfected patients in an Asian regional cohort. Methods: Adult HIV/TB-coinfected patients in an observational HIV-infected cohort database who had a known date of ART initiation and a history of TB treatment were eligible for study inclusion. The time interval between the initiation of ART and the initiation of TB treatment was categorized as follows: TB diagnosed while on ART, ART initiated ≤90 days after initiation of TB treatment ('early ART'), ART initiated >90 days after initiation of TB treatment ('delayed ART'), and ART not started. Outcomes were assessed using survival analyses. Results: A total of 768 HIV/TB-coinfected patients were included in this study. The median CD4 T-cell count at TB diagnosis was 100 [interquartile range (IQR) 40-208] cells/μL. Treatment outcomes were not significantly different between the groups with early ART and delayed ART initiation. Kaplan-Meier analysis indicated that mortality was highest for those diagnosed with TB while on ART (3.77 deaths per 100 person-years), and the prognoses of other groups were not different (in deaths per 100 person-years: 2.12 for early ART, 1.46 for delayed ART, and 2.94 for ART not started). In a multivariate model, the interval between ART initiation and TB therapy initiation did not significantly impact all-cause mortality. Conclusions: A negative impact of delayed ART in patients coinfected with TB was not observed in this observational cohort of moderately to severely immunosuppressed patients. The broader impact of earlier ART initiation in actual clinical practice should be monitored more closely. © 2013 British HIV Association.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/34311

Collections

Scopus 2011-2015