Publication:
Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster

Issued Date

2007-03-16

Resource Type

Article

ISSN

10902104
0006291X

DOI

10.1016/j.bbrc.2007.01.056

Other identifier(s)

2-s2.0-33846829603

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Biochemical and Biophysical Research Communications. Vol.354, No.3 (2007), 789-794

Suggested Citation

Nongluk Plongthongkum, Niwed Kullawong, Sakol Panyim, Witoon Tirasophon Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster. Biochemical and Biophysical Research Communications. Vol.354, No.3 (2007), 789-794. doi:10.1016/j.bbrc.2007.01.056 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24230

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Title

Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster

Author(s)

Nongluk Plongthongkum
 Niwed Kullawong
 Sakol Panyim
 Witoon Tirasophon

Other Contributor(s)

Mahidol University

Abstract

The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress. © 2007 Elsevier Inc. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/24230

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Scopus 2006-2010