Publication: Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria
Issued Date
1997-01-01
Resource Type
ISSN
00359203
Other identifier(s)
2-s2.0-0031446056
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Mahidol University
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SCOPUS
Bibliographic Citation
Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.91, No.6 (1997), 694-696
Suggested Citation
W. Supanaranond, Y. Suputtamongkol, T. M.E. Davis, S. Pukrittayakamee, P. Teja-Isavadharm, H. K. Webster, N. J. White Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.91, No.6 (1997), 694-696. doi:10.1016/S0035-9203(97)90528-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17991
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Title
Lack of a significant adverse cardiovascular effect of combined quinine and mefloquine therapy for uncomplicated malaria
Abstract
Quinine dihydrochloride (10 mg salt/kg infused over one hour) and mefloquine (15 mg base/kg) were given simultaneously to 13 adults with uncomplicated falciparum malaria. Supine and standing blood pressures were recorded and the electrocardiogram monitored. Plasma concentrations of the 2 drugs were similar to those reported previously for the 2 compounds given individually to a similar group of patients. Although postural hypotension was common (6 cases before treatment and 7 after) and the electrocardiogram QT(c) interval was prolonged by a mean of 12% (SD = 8) following drug treatment, there was no evidence of a clinically significant cardiovascular pharmacodynamic interaction between these 2 structurally related antimalarial compounds.